Article
Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Oct 2017
Taguchi Yumiko V, Liu Jun, Ruan Jiapeng, Pacheco Joshua, Zhang Xiaokui, Abbasi Justin, Keutzer Joan, Mistry Pramod K, Chandra Sreeganga S
Abstract excerpt
Glucocerebrosidase 1 (GBA) mutations responsible for Gaucher disease (GD) are the most common genetic risk factor for Parkinson's disease (PD). Although the genetic link between GD and PD is well established, the underlying molecular mechanism(s) are not well understood. We propose that glucosylsphingosine, a sphingolipid accumulating in GD, mediates PD pathology in GBA-associated PD. We show that, whereas...
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