Article

Minimally Invasive In-Situ Perfusion Method for Targeted AAV Delivery in Native Kidney: Proof of Concept in Pigs

2026-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Currently, there is not any method for efficient and targeted delivery of gene therapies using viral vectors to the native kidneys. Adeno-associated viruses (AAV) are limited by hepatotoxicity and poor kidney tropism. This study aimed to develop a minimally invasive approach that overcomes both challenges. We evaluated in pigs a technique leveraging external perfusion systems to transiently isol...

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Literature Corpus work: d3188b9a-9cff-5829-83a6-a4f51d43d925
DOI: 10.64898/2026.01.03.697116

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