Article

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

2023-03-04

Abstract excerpt

<h4>Summary</h4> Toxicity by recombinant adeno-associated viruses (rAAV) in clinical gene therapy trials (e.g., by rAAV9-mediated fatal liver failure) significantly impairs translation of preclinical rAAV-based cardiac gene therapies employing these vectors. For rAAV5 - a capsid that has shown long-term safety in clinical trials - our translational study demonstrates effective transduction of the left ventricle (...

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Literature Corpus work: d4395e03-3101-56c4-b2b7-772d74e069a5
DOI: 10.1101/2023.03.03.529004

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