Article

Harnessing the power of whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

2023-07-24

Abstract excerpt

<title>Abstract</title> <p>Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of personalized medicine. Liver-directed gene therapies present a unique challenge due to the complexity of the human liver. In this work, we describe the application of whole human liver explants in an ex situ normothermic perfusion syst...

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Literature Corpus work: cca9350c-9f20-5c06-a198-df26ee4f60c5
DOI: 10.21203/rs.3.rs-3158964/v1

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