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Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids

2023-07-29

Abstract excerpt

Despite recent remarkable advancements in adeno-associated virus (AAV) vector technologies, effective gene delivery to the kidney remains a significant challenge. Here we show that AAV vector transduction in proximal tubules and podocytes, the crucial targets for renal gene therapy, can be enhanced remarkably through a meticulous selection of both AAV capsids and route of administration, tailored to the condition...

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Identifiers and source

Literature Corpus work
1dfa73dc-8f85-5b82-9bec-cebc832b07f1
DOI
10.1101/2023.07.28.548760
Open publication

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Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsidsDOI 10.1101/2023.07.28.548760
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