Article

AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model

2024-05-29

Abstract excerpt

In gene therapy, delivery vectors are a key component for successful gene delivery and safety, based on which adeno-associated viruses (AAVs) gained popularity in particular for the liver, but also for other organs. Traditionally, rodents have been used as animal models to develop and optimize treatments, but species and organ specific tropism of AAV desire large animal models more closely related to humans for pr...

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Literature Corpus work: 1ffc3491-4f52-51af-bd14-708ccad99ea4
DOI: 10.1101/2024.05.29.596409

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