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Article

Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound-guided percutaneous transhepatic portal vein injection

2023-04-05

Abstract excerpt

One challenge for liver-directed gene therapy is sufficient vector delivery to the target tissue while minimizing loss of the applied vector dose to other tissues. Infusion via peripheral veins is the least invasive approach; however, it results in systemic diffusion and substantial vector dilution. Here, we describe a safe and minimally invasive method to deliver adeno-associated virus (AAV) vectors to the liver...

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Identifiers and source

Literature Corpus work
dd39485f-17cc-56cc-83c6-d2a40d2d10cf
DOI
10.1101/2023.04.05.535660
Open publication

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Safe delivery of AAV vectors to the liver of small weaned pigs by ultrasound-guided percutaneous transhepatic portal vein injectionDOI 10.1101/2023.04.05.535660
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