Article

Harnessing the power of whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

2023-07-10

Abstract excerpt

Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of personalized medicine. Liver-directed gene therapies present a unique challenge due to the complexity of the human liver. In this work, we describe the application of whole human liver explants in an ex situ normothermic perfusion system to evaluate a set of fou...

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Literature Corpus work: 118b3bc7-fe55-52c3-aba5-be3da20c77c4
DOI: 10.1101/2023.07.10.548299

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