Efficient delivery of gene editors using intein-engineered virus-like particles

Abstract excerpt

Virus-like particles (VLPs) represent a promising next-generation drug delivery platform. However, conventional VLPs rely on multiple viral components for effective cargo encapsulation and delivery, raising safety concerns. Here, we present a novel strategy to engineer immature VLPs using a self-cleaving intein system. We employed viral Gag proteins as sorting domains, linking cargo proteins to Gag through inteins...

Topics

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• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Extracellular Vesicles
• Extracellular vesicles in disease
• Gene Editing
• Gene Transfer Techniques
• Mutation
• RNA

Identifiers and source

Literature Corpus work

d30f5fa4-53ea-59d0-b134-d12a771f08ac

DOI

10.64898/2026.01.25.701600