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New Advances in Using Virus-like Particles and Related Technologies for Eukaryotic Genome Editing Delivery

6 Aug 2022

Abstract excerpt

The designer nucleases, including Zinc Finger Nuclease (ZFN), Transcription Activator-Like Effector Nuclease (TALEN), and Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated (CRISPR/Cas), have been widely used for mechanistic studies, animal model generation, and gene therapy development. Clinical trials using designer nucleases to treat genetic diseases or cancers are showing promising...

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PMID: 35955895
DOI: 10.3390/ijms23158750

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