Article

Psychiatric risk gene <i>NT5C2</i> regulates protein translation in human neural progenitor cells

2018-11-12

Abstract excerpt

Genome-wide significant variants associated with combined risk for major psychiatric disorders on chromosome 10q24 affect the expression of the cytosolic 5’-nucleotidase II ( NT5C2, cN-II ) in population controls, implicating it as a psychiatric susceptibility gene. Risk alleles are associated with reduced expression of this gene in the developing and adult brain, but the resulting neurobiological risk mechanisms...

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Literature Corpus work: d30e9a1c-cdf2-5e03-b766-cd79cb7df32e
DOI: 10.1101/468546

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