Article

Genetic association of FMRP targets with psychiatric disorders

2020-02-24

Abstract excerpt

<h4> A bstract </h4> Genes encoding the mRNA targets of Fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric disorders, including synaptic transmission and plasticity, making it unclear whether the genetic risk is truly related to binding by FMRP or is...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b711e154-3d4e-575f-bbc5-e3f10200422e
DOI: 10.1101/2020.02.21.952226

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic association of FMRP targets with psychiatric disordersDOI 10.1101/2020.02.21.952226Read

Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disordersSemantic proximity Read

Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.Semantic proximity Read

A polygenic burden of rare disruptive mutations in schizophrenia.Semantic proximity Read

The roles of FMRP-regulated genes in autism spectrum disorder: single- and multiple-hit genetic etiologies.Semantic proximity Read

Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies.Semantic proximity Read

Oligogenic rare variant contributions in schizophrenia and their convergence with genes harbouring <i>de novo</i> mutations in schizophrenia, autism and intellectual disability: Evidence from multiplex familiesSemantic proximity Read

Psychiatric gene discoveries shape evidence on ADHD's biology.Semantic proximity Read

Long-read nanopore sequencing reveals novel common genetic structural variants in Prader-Willi syndrome and associated psychosisSemantic proximity Read

Gene-set analysis shows association between FMRP targets and autism spectrum disorder.Semantic proximity Read

Genome-wide landscape of RNA-binding protein dysregulation reveals a major impact on psychiatric disorder riskSemantic proximity Read

De novo mutations in schizophrenia implicate synaptic networks.Semantic proximity Read

Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders.Semantic proximity Read