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Co-evolution of Oncogenic KRAS Signaling and LILRB <sup>high</sup> Macrophages Drives Pancreatic Cancer Recurrence

2026-03-07

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) frequently recurs after surgical resection, indicating that residual disease is sustained by coordinated tumor–microenvironment interactions. To define the biological basis of recurrence, we leverage large-scale clinical data from 2,710 patients, deeply characterized multi-omics profiling (whole-exome, bulk RNA, and single-nucleus sequencing) of 36 matched primary and locall...

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Literature Corpus work
d2c7b6a5-7f57-5a06-9561-d304e6576fe4
DOI
10.64898/2026.03.05.709991
Open publication

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Co-evolution of Oncogenic KRAS Signaling and LILRB <sup>high</sup> Macrophages Drives Pancreatic Cancer RecurrenceDOI 10.64898/2026.03.05.709991
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