Article

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with <i>KRAS-TP53</i> Co-Alteration in Pancreatic Cancer

2022-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS - TP53 co-alteration is associated with worse survival compared with either KRAS -alone or TP53 -alone altered PDAC in 245 patients with metastatic disease treated at a tertiary referral cancer center, and v...

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Literature Corpus work: 2d3b3e8e-f4b6-52ee-b2a1-5c4e4765ebfb
DOI: 10.1101/2022.05.01.490244

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