Article

Conserved yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X Protein

2024-10-28

Abstract excerpt

Hepatitis B virus (HBV), belonging to the genus Orthohepadnavirus , can cause chronic hepatitis and hepatocarcinoma in humans. HBV ensures optimal replication by encoding X, a multifunctional protein responsible for degrading the structural maintenance of the chromosome (Smc) 5/6 complex, an anti-HBV factor in hepatocytes. Previous studies suggest that the degradation activity of the Smc5/6 complex is conserved a...

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Literature Corpus work: d2bdb711-7543-53db-8074-7fac64186ff6
DOI: 10.1101/2024.10.28.620692

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