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HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA

31 Aug 2021

Abstract excerpt

BACKGROUND & AIMS: HBV causes hepatocellular carcinoma (HCC). While it was recently shown that the ability of HBV X protein (HBx) to impair the Smc5/6 (structural maintenance of chromosome 5/6) complex is important for viral transcription, HBx is also a potent driver of HCC. However, the mechanism by which HBx expression induces hepatocarcinogenesis is unclear. METHODS: Degradation of the Smc5/6 complex and...

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PMID: 34478763
DOI: 10.1016/j.jhep.2021.08.010

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