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Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

1 Sept 2016

Abstract excerpt

The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified the structural maintenance of chromosomes (SMC) complex proteins SMC5 and SMC6 as CRL4(HBx) substrates. HBx expression and HBV...

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Identifiers

PMID: 27626656
DOI: 10.1016/j.celrep.2016.08.026

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