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Article

Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals.

Journal of virology - 15 Aug 2018

Abdul Fabien, Filleton Fabien, Gerossier Laetitia, Paturel Alexia, Hall Janet, Strubin Michel, Etienne Lucie

Abstract excerpt

Chronic infection with hepatitis B virus (HBV) is a major cause of liver disease and cancer in humans. HBVs (family Hepadnaviridae) have been associated with mammals for millions of years. Recently, the Smc5/6 complex, known for its essential housekeeping functions in genome maintenance, was identified as an antiviral restriction factor of human HBV. The virus has, however, evolved to counteract this defense...

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Identifiers

PMID: 29848586
DOI: 10.1128/JVI.00769-18
PMCID: PMC6069175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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