Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

17 Jan 2017

Abstract excerpt

The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing HBV X protein (HBx), which targets Smc5/6 for degradation. However, the mechanism by which Smc5/6 suppresses HBV transcription and how HBx is initially expressed is not known. In this study we characterized viral kinetics and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Hepatitis C virus research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28095508
DOI: 10.1371/journal.pone.0169648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after InfectionPMID 28095508Read ↗

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human HepatocytesSemantic proximity Read ↗

Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals.Semantic proximity Read ↗

Conserved yet Divergent Smc5/6 Complex Degradation by Mammalian Hepatitis B Virus X ProteinSemantic proximity Read ↗

HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNASemantic proximity Read ↗

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV ReplicationSemantic proximity Read ↗

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivoSemantic proximity Read ↗

Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc5/6Semantic proximity Read ↗

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase ComplexSemantic proximity Read ↗

E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation.Semantic proximity Read ↗

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin stateSemantic proximity Read ↗

The SMC5/6 Complex Represses the Replicative Program of High-Risk Human Papillomavirus Type 31Semantic proximity Read ↗

Human cytomegalovirus antagonizes SMC5/6 driven genome silencing via UL35 instituted proteasomal degradation of SLF2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.