Article

Spatial molecular imaging of the human type 2 diabetic islet

2023-01-04

Abstract excerpt

<h4>ABSTRACT</h4> The islets of Langerhans are complex micro-organs comprised of multiple cell types essential for the maintenance of glucose homeostasis. The endocrine cell types of the islets engage in intimate, intercellular communication that is necessary for normal secretory activity. Disruption of this intercellular communication, which is at least partially dependent on the spatial organization of individu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2ac2500-b354-5655-871c-2a2cf498b074
DOI: 10.1101/2023.01.04.519955

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial molecular imaging of the human type 2 diabetic isletDOI 10.1101/2023.01.04.519955Read

The Spatial Landscape of Extracellular Matrix Gene Expression in Healthy and Type 2 Diabetic Human PancreasSemantic proximity Read

Illuminating the complete ß-cell mass of the human pancreas - signifying a new view on the islets of LangerhansSemantic proximity Read

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes.Semantic proximity Read

Single-cell genomics and spatial transcriptomics in islet transplantation for diabetes treatment: advancing towards personalized therapiesSemantic proximity Read

Interrogating islets in health and disease with single-cell technologiesSemantic proximity Read

Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.Semantic proximity Read

Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic diseaseSemantic proximity Read

Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetesSemantic proximity Read

Deep tissue optical 3D imaging reveals preferential preservation of extra-islet β-cells in late-onset Type 1 DiabetesSemantic proximity Read

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network ScienceSemantic proximity Read

Small things matter: Lack of extra-islet beta cells in Type 1 diabetesSemantic proximity Read

Integrative Spatial Omics for Systems-Level Mapping of Pathological NichesSemantic proximity Read