Article

The Spatial Landscape of Extracellular Matrix Gene Expression in Healthy and Type 2 Diabetic Human Pancreas

2026-07-01

Abstract excerpt

The unique peri-islet and double-layered vascular basement membrane (BM) of the human pancreatic islet are critical regulators of beta cell survival and function. While animal models imply that endothelial cells (ECs) are the exclusive source of islet BM, the precise cellular origins and spatial organization of the human islet matrisome remain poorly defined due to overlap in genes that mark non-epithelial cell po...

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Literature Corpus work: 32e71482-03c5-54e1-b3ee-998a3d818c0e
DOI: 10.64898/2026.06.30.733275

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