Article

A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

2022-05-22

Abstract excerpt

T-cell Acute Lymphoblastic Leukemia (T-ALL) is a NOTCH1-driven disease in need of novel therapies. Here, we identify a NOTCH1-SIRT1-KAT7 link as a therapeutic vulnerability in T-ALL, in which SIRT1 is overexpressed downstream of a novel NOTCH1-bound enhancer. SIRT1 loss impairs leukemia generation, while SIRT1 overexpression accelerates leukemia and confers resistance to NOTCH1 inhibition in a deacetylase-dependen...

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Literature Corpus work: d2a95cd1-d489-537d-94b3-805d050da834
DOI: 10.1101/2022.05.21.492944

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