Article

DDX3 Regulates the Innate Immune Response to Bone Sarcomas

2026-07-02

Abstract excerpt

Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common malignant bone tumors in children and adolescents, with survival rates around 25% in metastatic disease and few advances in treatment in decades. High DDX3 expression has been reported across various sarcoma subtypes. Depending on the context, DDX3 appears to have opposing roles in regulating the tumor immune microenvironment. Within macrophages, DDX3 p...

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Literature Corpus work: d2a7bbca-b4ed-5203-bd9e-e240cac80ea7
DOI: 10.64898/2026.07.01.735844

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