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Article

Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models

30 Aug 2024

Abstract excerpt

SET and MYND-domain containing protein 3 (SMYD3) mediates epigenetic repression of type I IFN response genes in human papillomavirus (HPV)-negative HNSCC cells, and Smyd3 depletion using anti-sense oligonucleotides (ASOs) increases the sensitivity of syngeneic mouse oral carcinoma (MOC1) models to anti-PD-1 therapy. In this study, we utilized single-cell RNA-seq of MOC1 tumors treated with Smyd3 ASOs and found...

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Identifiers

PMID: 39310755
DOI: 10.1016/j.isci.2024.110854

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