Article

Long-Term Intra-Host Evolution of SARS-CoV-2 in an Immunocompromised Patient: Recombination and Within-Host Mutations Driving Viral Adaptation

2025-03-26

Abstract excerpt

An immuno-compromised patient with lymphoma experienced a prolonged SARS-CoV-2 infection lasting 14 months, initially infected with B.1.160, followed by B.1.1.7. This study focused on intra-host single nucleotide variants (iSNVs) and single nucleotide polymorphisms (SNPs), distinguishing their origin as either within-host mutations or parental. The whole genome analysis revealed accelerated evolution, with positiv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d27d5109-c689-5837-bf7e-5f79874ecffa
DOI: 10.1101/2025.03.25.645210

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Long-Term Intra-Host Evolution of SARS-CoV-2 in an Immunocompromised Patient: Recombination and Within-Host Mutations Driving Viral AdaptationDOI 10.1101/2025.03.25.645210Read

Large-scale population analysis of SARS-CoV-2 whole genome sequences reveals host-mediated viral evolution with emergence of mutations in the viral Spike protein associated with elevated mortality ratesSemantic proximity Read

Intra-host evolution provides for continuous emergence of SARS-CoV-2 variantsSemantic proximity Read

Intra-host evolution during SARS-CoV-2 persistent infectionSemantic proximity Read

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised hostSemantic proximity Read

Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants.Semantic proximity Read

Intra-host viral populations of SARS-CoV-2 in immunosuppressed patients with hematologic cancersSemantic proximity Read

Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma.Semantic proximity Read

Intra-host evolution during SARS-CoV-2 prolonged infectionSemantic proximity Read

SARS-CoV-2 variants in the making: Sequential intrahost evolution and forward transmissions in the context of persistent infectionsSemantic proximity Read

Impact of prolonged infection on SARS-CoV-2 evolution.Semantic proximity Read

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.Semantic proximity Read

Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host.Semantic proximity Read