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Article

Impact of prolonged infection on SARS-CoV-2 evolution.

Microbiology spectrum - 6 Jan 2026

Yan Fang, Jin Qiushi, Li Yuanguo, Wang Xuefeng, Dong Chunling, Xia Xianzhu, Gao Yuwei, Zhang Jie, Hou Zhijun

Abstract excerpt

Immunocompromised patients with prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may serve as reservoirs for viral evolution, with suboptimal immune responses facilitating the accumulation of adaptive mutations. This study aimed to characterize the drivers of SARS-CoV-2 adaptive evolution in such hosts through genomic surveillance. We retrospectively analyzed 24 patients with...

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Identifiers

PMID: 41496159
DOI: 10.1128/spectrum.02432-25
PMCID: PMC12772307

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