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Impact of prolonged infection on SARS-CoV-2 evolution.

Microbiology spectrum - 6 Jan 2026

Yan Fang, Jin Qiushi, Li Yuanguo, Wang Xuefeng, Dong Chunling, Xia Xianzhu, Gao Yuwei, Zhang Jie, Hou Zhijun

Abstract excerpt

Immunocompromised patients with prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may serve as reservoirs for viral evolution, with suboptimal immune responses facilitating the accumulation of adaptive mutations. This study aimed to characterize the drivers of SARS-CoV-2 adaptive evolution in such hosts through genomic surveillance. We retrospectively analyzed 24 patients with...

Topics

Humans
SARS-CoV-2
Mutation
Phylogeny
Evolution, Molecular
COVID-19
Immunocompromised Host
Female
Retrospective Studies
Male
Middle Aged
Spike Glycoprotein, Coronavirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Genome, Viral

HeLa Cells

Virus Replication

HIV Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 41496159
DOI: 10.1128/spectrum.02432-25
PMCID: PMC12772307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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