Article
Unraveling the Role of Transcription Factor SP1 and H3K9 Acetylation in MGMT Regulation and Temozolomide Resistance in Glioblastoma Multiforme
2023-10-09
Abstract excerpt
Glioblastoma multiforme (GBM) is recognized as a highly aggressive brain tumor, exhibiting profound resistance to temozolomide (TMZ) chemotherapy. While methylation of the MGMT promoter has been identified as a significant factor determining the response to TMZ, recent evidence indicates that the regulatory mechanisms are multifaceted, involving complex interplays with broader epigenetic and transcriptional landsc...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- d277f56d-c37d-5e0c-9b2e-b1974eac5568
- DOI
- 10.21203/rs.3.rs-3398493/v1