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Regulatory mechanisms of O6-methylguanine methyltransferase expression in glioma cells

1 Apr 2025

Abstract excerpt

O6-methylguanine methyltransferase (MGMT), a pivotal DNA repair enzyme, has its dysregulation playing a substantial role in gliomagenesis, the development of therapeutic resistance, and patient prognosis. This narrative review is designed to offer an all-encompassing overview of the intricate regulatory mechanisms that govern MGMT expression in glioma cells. We systematically investigate the diverse levels of...

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Share to Epigenetics and DNA Methylation
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PMID: 40519114
DOI: 10.1177/00368504251345014

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