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Network Analysis of Inflammatory Bowel Disease Reveals PTPN2 As New Monogenic Cause of Intestinal Inflammation

2019-09-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND & AIMS</h4> Genome-wide association studies (GWAS) have uncovered multiple loci associated with inflammatory bowel disease (IBD), yet delineating functional consequences is complex. We used a network-based approach to uncover traits common to monogenic and polygenic forms of IBD in order to reconstruct disease relevant pathways and prioritize causal genes. <h4>METHODS</h4> We ha...

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Literature Corpus work: d26f3caf-2547-5faf-b24d-216f412e379f
DOI: 10.1101/768028

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