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MYO5B and the Polygenic Landscape of Very Early-Onset Inflammatory Bowel Disease in an Ethnically Diverse Population.

Inflammatory bowel diseases - 6 Jan 2025

Watson Ashleigh, Harris R Alan, Engevik Amy C, Oezguen Numan, Nicholson Maribeth R, Dooley Sarah, Stubler Rachel, Satter Lisa Forbes, Karam Lina B, Kellermayer Richard

Abstract excerpt

BACKGROUND: Genetic discovery in very early-onset inflammatory bowel disease (VEO-IBD) can elucidate not only the origins of VEO-IBD, but also later-onset inflammatory bowel disease. We aimed to investigate the polygenic origins of VEO-IBD in a cohort with a high proportion of Hispanic patients. METHODS: Patients with VEO-IBD who underwent whole exome sequencing at our center were included. Genes were categorized...

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Age of Onset
Child, Preschool
Exome Sequencing
Hispanic or Latino
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammatory Bowel Diseases

Multifactorial Inheritance

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PMID: 39096520
DOI: 10.1093/ibd/izae169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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