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Article

The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis.

Developmental biology - 15 Dec 2008

Patel Falshruti B, Bernadskaya Yelena Y, Chen Esteban, Jobanputra Aesha, Pooladi Zahra, Freeman Kristy L, Gally Christelle, Mohler William A, Soto Martha C

Abstract excerpt

The WAVE/SCAR complex promotes actin nucleation through the Arp2/3 complex, in response to Rac signaling. We show that loss of WVE-1/GEX-1, the only C. elegans WAVE/SCAR homolog, by genetic mutation or by RNAi, has the same phenotype as loss of GEX-2/Sra1/p140/PIR121, GEX-3/NAP1/HEM2/KETTE, or ABI-1/ABI, the three other components of the C. elegans WAVE/SCAR complex. We find that the entire WAVE/SCAR complex...

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Identifiers

PMID: 18938151
DOI: 10.1016/j.ydbio.2008.09.023
PMCID: PMC2629559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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