Article

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

2023-03-25

Abstract excerpt

<h4>SUMMARY</h4> Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that ‘hybrid’ neutrophils with dendritic features – including morphological complexity, expression of antigen presentation genes, and the ability to process exogenous peptide and stimulate MHCII-dependent T cell activation – accumulate intratumorally and suppress tumor growth in vivo . Traj...

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Identifiers and source

Literature Corpus work: 49c7104c-fe9b-5d54-bfac-99ae7cc9791e
DOI: 10.1101/2023.03.24.534105

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