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Article

Genome editing in mouse spermatogonial stem/progenitor cells using engineered nucleases.

PloS one - 1 Jan 2014

Fanslow Danielle A, Wirt Stacey E, Barker Jenny C, Connelly Jon P, Porteus Matthew H, Dann Christina Tenenhaus

Abstract excerpt

Editing the genome to create specific sequence modifications is a powerful way to study gene function and promises future applicability to gene therapy. Creation of precise modifications requires homologous recombination, a very rare event in most cell types that can be stimulated by introducing...

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Identifiers

PMID: 25409432
DOI: 10.1371/journal.pone.0112652
PMCID: PMC4237364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25409432-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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