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First-in-Human Dengue Serotype 4 Live Virus Human Challenge: A Phase 1 Dose Optimization and Homologous Rechallenge Study

2025-11-01

Abstract excerpt

<title>Abstract</title> <p>Dengue Live Virus Human Challenges (LVHC) are critically needed in dengue vaccine and pharmacologic development to down-select candidates and provides a useful platform for understanding viral-host immunology in a controlled setting. We conducted a first-in-human phase 1 open label study evaluating the safety and optimized dose of an underattenuated dengue virus serotype-4-LVHC (DENV-4-...

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Literature Corpus work
d20ba0b7-acba-5b8e-916f-f6cd4e06dba1
DOI
10.21203/rs.3.rs-7947800/v1
Open publication

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First-in-Human Dengue Serotype 4 Live Virus Human Challenge: A Phase 1 Dose Optimization and Homologous Rechallenge StudyDOI 10.21203/rs.3.rs-7947800/v1
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