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Preexisting Enhancing Antibodies in Vaccinated Participants Accelerate Dengue Virus 1 Infection Following Live Virus Human Challenge

2023-09-15

Abstract excerpt

<title>Abstract</title> <p>Dengue Human Infection Models (DHIM) are needed to down-select dengue vaccine candidates and establish tetravalent efficacy before advanced clinical field trials. As part of a randomized heterologous prime-boost vaccine strategy, participants received a tetravalent dengue (TDEN) Purified Inactivated Vaccine (PIV) prime followed by a TDEN Live Attenuated Vaccine (LAV) boost at 28, 90 or...

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Identifiers and source

Literature Corpus work
608517d1-df6a-594b-8f90-cc67192e2a9a
DOI
10.21203/rs.3.rs-3237925/v1
Open publication

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Preexisting Enhancing Antibodies in Vaccinated Participants Accelerate Dengue Virus 1 Infection Following Live Virus Human ChallengeDOI 10.21203/rs.3.rs-3237925/v1
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