Article
The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model
16 Mar 2016
Abstract excerpt
A dengue human challenge model can be an important tool to identify candidate dengue vaccines that should be further evaluated in large efficacy trials in endemic areas. Dengue is responsible for about 390 million infections annually. Protective efficacy results for the most advanced dengue vaccine candidate (CYD) were disappointing despite its ability to induce neutralizing antibodies against all four dengue...