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Article

Engineering functional human vasculature: iPSC-derived vascular cells and organoids for disease modeling and translation.

Vascular pharmacology - 1 Sept 2026

Jiang Chonggui, Cui Pan, Gong Liyan

Abstract excerpt

Human vascular function depends on tightly coordinated structural, mechanical, and cellular interactions, yet these features remain difficult to recapitulate in vitro. Induced pluripotent stem cells (iPSCs) enable efficient generation of vascular cell types, including endothelial cells, smooth muscle cells, and pericytes, but current systems often lack functional maturity and physiological relevance. Recent...

Read the complete abstract on PubMed

Topics

Humans
Induced Pluripotent Stem Cells
Organoids
Tissue Engineering
Cell Differentiation
Animals
Endothelial Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Translational Research, Biomedical

Vascular Diseases

Myocytes, Smooth Muscle

Microphysiological Systems

Phenotype

Source

Identifiers

PMID: 42537971
DOI: 10.1016/j.vph.2026.107683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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