Article

Shear stress and very low levels of ligand synergize to activate ALK1 signaling in endothelial cells

2023-11-03

Abstract excerpt

Endothelial cells (ECs) respond to concurrent stimulation by biochemical fac-tors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed mechanisms linking flow-mechanical cues and biochemical signaling remain unclear. Activin receptor-like kinase 1 (ALK1) integrates SS and ALK1-ligand cues in ECs; ALK1 m...

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Literature Corpus work: 78c7fe88-dc83-5448-b77c-cef8e2acf499
DOI: 10.1101/2023.11.01.565194

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