Article

Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles

2025-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Overexpression of checkpoint proteins, such as programmed death ligand one (PD-L1), prevents immune recognition and enables cancer growth. Current monoclonal antibodies that block PD-L1 tend to be fragile, unable to penetrate tumors, and target cancer at later stages, thus leading to inconsistent patient outcomes. Antisense oligonucleotides (ASOs) provide an alternative to decrease PD-L1 express...

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Literature Corpus work: d1de08a3-5b74-5ed0-b60f-845b6c938218
DOI: 10.1101/2025.03.28.645811

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