Modular platform for therapeutic drug delivery using trifunctional bio-orthogonal macromolecular conjugates

Abstract excerpt

Targeted delivery of macromolecular therapeutics holds great promise for overcoming the limitations of conventional small molecules, enabling modulation of protein-protein interactions and precise genome editing. However, efficient, safe, and cell type-specific delivery remains a major challenge. To address this, we developed a modular platform for synthesizing heterotrifunctional bio-orthogonal macromolecular con...

Topics

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• Cancer Research and Treatments
• CAR-T cell therapy research
• Chemical Synthesis and Analysis
• Click Chemistry and Applications
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

9202dde5-41dd-5552-9951-7274c149f715

DOI

10.1101/2025.07.24.666613