Article

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populations

2019-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Viral infection is usually studied at the population level by averaging over millions of cells. However, infection at the single-cell level is highly heterogeneous. Here, we combine live-cell imaging and single-cell RNA sequencing to characterize viral and host transcriptional heterogeneity during HSV-1 infection of primary human cells. We find extreme variability in the level of viral gene expr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd58716b-25f2-5913-b239-7cf8bdfb83d5
DOI: 10.1101/566489

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populationsDOI 10.1101/566489Read

HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populationsSemantic proximity Read

Functional single-cell genomics of human cytomegalovirus infectionSemantic proximity Read

Dynamic Proteomics of Herpes Simplex Virus Infection.Semantic proximity Read

Rainbow Kaposi's Sarcoma-Associated Herpesvirus Revealed Heterogenic Replication with Dynamic Gene ExpressionSemantic proximity Read

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral programSemantic proximity Read

Virus Infection Variability by Single-Cell ProfilingSemantic proximity Read

Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral programSemantic proximity Read

Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infectionSemantic proximity Read

Single-cell RNA-sequencing analysis identifies host long noncoding RNA MAMDC2-AS1 as a co-factor for HSV-1 nuclear transportSemantic proximity Read

Transcriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cellsSemantic proximity Read

Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progressionSemantic proximity Read

Herpesviruses mimic zygotic genome activation to promote viral replicationSemantic proximity Read