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Local Immune Control of Latent Herpes Simplex Virus Type 1 in Ganglia of Mice and Man

15 Sept 2021

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is a prevalent human pathogen. HSV-1 genomes persist in trigeminal ganglia neuronal nuclei as chromatinized episomes, while epithelial cells are typically killed by lytic infection. Fluctuations in anti-viral responses, broadly defined, may underlay periodic reactivations. The ganglionic immune response to HSV-1 infection includes cell-intrinsic responses in neurons, innate...

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PMID: 34603296
DOI: 10.3389/fimmu.2021.723809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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