Article

hPSC-Derived Distal Lung Organoids Reveal Respiratory Airway Secretory Cells Acting as Immune Sentinels in Human Distal Airways

2025-03-25

Abstract excerpt

Pulmonary immunity in the human distal respiratory airways is essential for lung function but remains poorly explored, mainly due to limited physiologically relevant models. Here, we develop distal lung organoids containing respiratory airway secretory (RAS) cells, a recently identified epithelial population unique to the distal airways of humans and large mammals, using human pluripotent stem cells (hPSCs). Linea...

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Literature Corpus work: d18aeeb2-2922-5e6c-9792-8e8ef9ca9c25
DOI: 10.1101/2025.03.24.644887

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