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Article

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

23 Aug 2019

Abstract excerpt

BACKGROUND: The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining the airways ≥ 6th generations. The basal cells (BC) are the stem/progenitor cells of the SAE, responsible for the differentiation into intermediate cells and ciliated, club and mucous cells. To...

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PMID: 31443657
DOI: 10.1186/s12931-019-1140-9

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