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Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

13 Aug 2021

Abstract excerpt

Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous immune response whose origin remains unclear. Methods: We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from adult lung organoids...

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PMID: 34463615
DOI: 10.7554/elife.66417

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