Article

The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

2023-01-27

Abstract excerpt

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes an acute respiratory distress syndrome (ARDS) that resembles surfactant deficient RDS. Using a novel multi-cell type, human induced pluripotent stem cell (hiPSC)-derived lung organoid (LO) system, validated against primary lung cells, we found that inflammatory cytokine/chemokine production and interferon (IFN) responses are dynamically regulated...

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Literature Corpus work: 3058c0c5-a753-52bd-95c0-447286592298
DOI: 10.1101/2023.01.26.525578

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