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Targeting BRD4 Ameliorates Experimental Emphysema by Disrupting Super-Enhancer in Polarized Alveolar Macrophage     

2024-01-02

Abstract excerpt

<h4>Background: </h4> Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease characterized by chronic airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis by secreting inflammatory mediators. Bromodomain-containing protein 4 (BRD4), an epigenetic reader that specifically binds to histones, plays a crucial role in inflammatory diseases b...

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Literature Corpus work
d153daeb-9179-5497-8757-4fb4a07db566
DOI
10.21203/rs.3.rs-3788052/v1
Open publication

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