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Expression of the naked mole-rat transgene for <i>Has2</i> improved health span in C57Bl/6 mice, but it did not attenuate age-related hearing loss

2025-07-31

Abstract excerpt

The naked mole-rat (NMR) is renowned for being the longest-lived rodent, with a maximum lifespan of over 40 years. This exceptional longevity has been attributed to increased cytoprotective signaling, which has been partially ascribed to a major component of the NMR’s extracellular matrix hyaluronan (HA), which has an unusually large molecular mass in this species. The HA molecular mass in the NMR is five to six t...

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Literature Corpus work: d1507888-2fae-5aee-9405-c3659e8dbfea
DOI: 10.1101/2025.07.27.667071

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