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CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

1 Sept 2023

Abstract excerpt

The naked mole rat (NMR) is the longest-lived rodent, resistant to multiple age-related diseases including neurodegeneration. However, the mechanisms underlying the NMR's resistance to neurodegenerative diseases remain elusive. Here, we isolated oligodendrocyte progenitor cells (OPCs) from NMRs and compared their transcriptome with that of other mammals. Extracellular matrix (ECM) genes best distinguish OPCs of...

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PMID: 37708026
DOI: 10.1016/j.celrep.2023.113130

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