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c.753A>G genome editing of a Cdh23ahl allele delays age-related hearing loss and degeneration of cochlear hair cells in C57BL/6J mice.

Hearing research - 1 Apr 2020

Yasuda Shumpei P, Seki Yuta, Suzuki Sari, Ohshiba Yasuhiro, Hou Xuehan, Matsuoka Kunie, Wada Kenta, Shitara Hiroshi, Miyasaka Yuki, Kikkawa Yoshiaki

Abstract excerpt

C57BL/6J mice have long been studied as a model of age-related hearing loss (ARHL). In C57BL/6J mice, ARHL begins in the high-frequency range at 3 months of age and spreads toward low frequencies by 10 months of age. We previously confirmed that c.753A>G genome editing of an ahl allele (c.753A) in the cadherin 23 gene (Cdh23) suppressed the onset of ARHL until 12 months of age. We further investigated the hearing...

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Share to Auditory Threshold
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32101784
DOI: 10.1016/j.heares.2020.107926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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